144 Adipose stem cell exosome (ASCE): Next generation regenerative therapeutics for atopic dermatitis

Objectives: 1. To find that ASCE can attenuate severe inflammation and promote skin barrier reconstruction in atopic dermatitis model. 2. understand adipose stem cell exosome (ASCE) be a paradigm shift regenerative aesthetics & therapeutics. Introduction: Exosomes, nano-sized extracellular vesicles, are the most important mediator for intercellular communication. For last years, dual function of regeneration anti-inflammation (Adipose Stem Cell Exosome) has been well known from number research. These days, ASCEs being developed as next generation therapeutics well. From our various studies, it shown an innovative biomaterial treatment rejuvenation. Materials / method: Human mesenchymal cell-derived exosomes were applied via SC or ID injection toin vitro models vivo animal models. In addition, one patient was topically with combination iontophoresis. Results: could reduce modulate over-reactive The AD score significantly improved up to 30% dose-dependent manner. Further, major proinflammatory cytokines including IL-4, IL-13, TLSP, others down-regulated by 30-50% promote, 40-70% manner, de novo synthesis ceramides dihydroceramides, key lipid molecules formation, which led significant improvement disruption Conclusion: proved have strong anti-inflammatory efficacy may serve variety inflammatory diseases dermatitis.